We study the genetic basis of complex traits and common diseases in humans. Our group is in the Department of Medical Genetics and of Epidemiology of University Medical Center Utrecht, and the Division of Genetics of the Brigham and Women's Hospital and Harvard Medical School. We are also affiliated with the Program in Medical and Population Genetics at the Broad Institute of Harvard and MIT.

A central goal of our lab is to develop computational tools and statistical approaches to analyze patterns of genetic variation in human populations, and to apply these methods to identify genetic determinants of disease susceptibility, disease progression, and drug response.

We pursue these activities in the context of immune-related disorders including HIV/AIDS and autoimmune disease, as well as cerebrovascular and cardiovascular traits, involving many collaborators in Boston and elsewhere.